Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties

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Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties.

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was investigated. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated. To evaluate any interaction be...

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A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

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A New Crystal Engineering Technique for Dissolution Enhancement of Poorly Soluble Drugs Combining Quasi-emulsion and Crystallo-co Agglomeration Methods

A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

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Solubility Enhancement of Poorly Water Soluble Drugs: a Review

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ژورنال

عنوان ژورنال: Acta Pharmaceutica

سال: 2007

ISSN: 1846-9558,1330-0075

DOI: 10.2478/v10007-007-0008-6